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MedicineWorld.Org brings daily research news from various sources to keep you updated on the latest events in the world on this topic. Medicineworld research news service is the most comprehensive research news service on the internet. We keep an archive of previous few days of news on this site. Please go down through the list to find the older news items |
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Smoking influences gene function
Wed, 14 Jul 2010 13:13:54 GMT
In the largest study of its kind, scientists at the Southwest Foundation for Biomedical Research (SFBR) have observed that exposure to cigarette smoke can alter gene expression -- the process by which a gene's information is converted into the structures and functions of a cell. These alterations in response to smoking appear to have a wide-ranging negative influence on the immune system, and a strong involvement in processes correlation to cancer, cell death and metabolism........
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Vitamin B3 to treat fungal infections
Wed, 14 Jul 2010 13:13:54 GMT
A team of researchers from the Institute for Research in Immunology and Cancer (IRIC) of the University of Montreal have identified vitamin B3 as a potential antifungal therapy. Led by IRIC Principal Investigators Martine Raymond, Alain Verreault and Pierre Thibault, in collaboration with Alaka Mullick, from the Biotechnology Research Institute of the National Research Council Canada, the study is the subject of a recent article in Nature Medicine.......
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Changing the cancer cell to respond to tamoxifen
Wed, 14 Jul 2010 13:13:54 GMT
Using a small molecule decoy, researchers funded by the Samuel Waxman Cancer Research Foundation have managed to block protein interactions and induce epigenetic reprogramming in human and mouse breast cancer cells, essentially changing the gene expression of breast cancer cells to behave in a more normal manner. The research illustrates what may perhaps become an effective targeted epigenetic treatment in breast cancer. Interestingly, the targeted therapy showed exciting results in triple-negative breast cancer cells, reverting their function and appearance, and sensitizing them to tamoxifen and retinoids........
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It takes more than antioxidants to slow aging
Wed, 14 Jul 2010 13:13:54 GMT
Don't put down the red wine and vitamins just yet, but if you're taking antioxidants because you hope to live longer, consider this: a newly released study reported in the June 2010 issue of the journal GENETICS (http://www.genetics.org) casts doubt on the theory that oxidative stress to our tissues shortens lifespan. That's because scientists from McGill University in Canada have identified mutations in 10 different genes of worms (genes believed to have counterparts in humans) that extend their lifespan without reducing the level of oxidative stress the worms suffer. The results contradict the popular theory that production of toxic reactive oxygen species in tissues is responsible for aging........
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DNA mutation as cause of cancer
Wed, 14 Jul 2010 13:13:54 GMT
What if we could understand why cancer develops? We know that certain risk factors, such as smoking or excessive sun exposure, can increase the chances of developing this terrible disease, but cancer can form in any tissue, and the cause is not always clear. One idea that has emerged is that for a cell to transform into a cancer cell it must suffer a large number of mutations affecting different genes needed to control cell growth. As per a research findings published this week in Science, Brandeis University scientists have observed that the process of repairing DNA damage also unexpectedly increases the rate of mutations and changes the kinds of mutations that arise........
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Loss of key protein promotes aggressive form of leukemia
Wed, 14 Jul 2010 13:13:54 GMT
Cold Spring Harbor, NY New research by researchers at Cold Spring Harbor Laboratory (CSHL) has illuminated in fine detail one of the genetic paths that leads to a especially aggressive form of leukemia. CSHL Professor Scott W. Lowe. Ph.D., an Investigator of the Howard Hughes Medical Institute, led a team of researchers who wanted to know more about how the absence of an important tumor-suppressing protein called p53 combines with another genetic "hit" in immature blood cells to give rise to acute myeloid leukemia, or AML. In experiments in living mice, the team discovered that if p53 is disabled in immature blood-cell "precursors" in which a mutation in a gene called Kras is also present, a built-in braking mechanism fails to engage and the cells proliferate out of control........
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Turning Back the Cellular Clock
Wed, 14 Jul 2010 13:13:54 GMT
Cell reprogramming calls The Curious Case of Benjamin Button to mind. It's a new technology that uses molecular treatment to coax adult cells to revert to an embryonic stem cell-like state, allowing researchers to later re-differentiate these cells into specific types with the potential to treat heart attacks or diseases such as Parkinson's. But at this point in the technology's development, only one percent of cells are successfully being reprogrammed........
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Antihypertensive against Alzheimer's disease
Wed, 14 Jul 2010 13:13:54 GMT
Scientists at Mount Sinai School of Medicine have observed that the drug carvedilol, currently prescribed for the therapy of hypertension, may lessen the degenerative impact of Alzheimer's disease and promote healthy memory functions. The new findings appear in two studies in the current issues of Neurobiology of Aging and the Journal of Alzheimer's Disease.......
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Gene Therapy A Step Closer
Wed, 14 Jul 2010 13:13:54 GMT
EUREKA project E! 3371 Gene Transfer Agents has made great advances in the development of novel non-viral carriers able to introduce genetic material into the target cells. These new agents, derivatives of cationic amphiphilic 1,4-dihydropyridine (1,4-DHP), avoid the problems of the recipient's immune system reacting against a viral carrier. The project partners have developed methods to produce them in large amounts, which solves another of the problems with viral delivery. But the greatest advantage is that the new compounds are significantly more effective at delivering DNA into cell nuclei than other standard synthetic carriers; increasing the chance of the DNA successfully controlling the defective genes, and the disease........
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Therapeutic potential of embryonic stem cells
Wed, 14 Jul 2010 13:13:54 GMT
The therapeutic potential of embryonic stem cells has been an intense focus of study and discussion in biomedical research and has resulted in technologies to produce human induced pluripotent stem cells (hiPSCs). Derived by epigenetic reprogramming of human fibroblasts, these hiPSCs are believed to be almost identical to human embryonic stem cells (hESCs) and provide great promise for patient-tailored regenerative medicine therapies. However, recent studies have suggested noteworthy differences between these two stem cell types which require additional comparative analyses........
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